Particular compounds current in grapefruit are recognized to inhibit CYP450 3A4 and could raise the bioavailability of swallowed fentanyl (reportedly nearly 75% of the dose) andAdult:Patches deliver fentanyl in doses that range between: 12-100 mcg/hr. Doses needs to be separately titrated dependant on former usage of opioids. Opioid-naive clients: